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KMID : 0043320140370020168
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Archives of Pharmacal Research
2014 Volume.37 No. 2 p.168 ~ p.174
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Structure and bioactivity of triterpenoids from the stems of Schisandra sphenanthera
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Liang Cheng Qin
Luo Rong Hua
Yan Ju Ming
Li Yan
Li Xiao Nian
Shi Yi Ming
Shang Shan Zhai
Gao Zhong Hua
Yang Liu Meng
Zheng Yong Tang
Xiao Wei Lie
Zhang Hong Bin
Sun Han Dong
Sun Han Dong
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Abstract
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Two new triterpenoids, schisphendilactone A and B (1 and 2), together with three known triterpenoids, were isolated from the stems of Schisandra sphenanthera. Their structures were elucidated by spectroscopic methods, and the absolute configuration of 1 was determined by single-crystal X-ray diffraction. Compound 2 showed moderate inhibitory activity against SW480 cancer cell line, and compound 5 exhibited promising anti-HIV-1 activity with EC50 value of 0.52 μg ml?1 and therapeutic index value of 117.12.
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KEYWORD
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Schisandra sphenanthera, Triterpenoid, Cytotoxicity, Anti-HIV-1
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